A7127
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A7127
Sigma
Agmatine sulfate salt
≥97%, powder
| Synonym: | 1-Amino-4-guanidinobutane sulfate salt, 4-Guanidinobutylamine sulfate salt, N-(4-Aminobutyl)guanidine sulfate salt |
| CAS Number: | 2482-00-0 |
| Linear Formula: | H2N(CH2)4NHC(=NH)NH2·H2SO4 |
| Molecular Weight: | 228.27 |
| Beilstein Registry Number: | 3918807 |
| EC Number: | 219-617-3 |
| MDL number: | MFCD00013109 |
| PubChem Substance ID: | 24277749 |
Description
| Biochem/physiol Actions | Putative endogenous neurotransmitter at imidazoline receptors; displaces clonidine at α2-adrenergic and at imidazoline receptors; blocks NMDA-activated ion channels in hippocampal neurons. |
Properties
| assay | ≥97% |
| form | powder |
| color | white to off-white |
| mp | 234-238 °C(lit.) |
| solubility | H2O: 50 mg/mL |
| ethanol: insoluble | |
| Gene Information | human ... ADRA2A(150), ADRA2B(151), ADRA2C(152), GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRINA(2907) |
Safety
| Personal Protective Equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
References
| reference | Reis, D.J., and Regunathan, S., Is agmatine a novel neurotransmitter in brain? Trends Pharmacol. Sci. 21, 187-193, (2000) Abstract |
| Yang, Y.C., and Reis, D.J., Agmatine selectively blocks the N-methyl-D-aspartate subclass of glutamate receptor channels in rat hippocampal neurons. J. Pharmacol. Exp. Ther. 288, 544-549, (1999) Abstract | |
| Li, et al., Agmatine: An endogenous clonidine-displacing substance in the brain. Science 263, 966, (1994) Abstract | |
| Merck | Merck 13,188 |
| Beilstein | Beil. 4,IV,1291 |
| FT-IR 2 (1), 1392:C / FT-IR 1 (1), 821:B / FT-NMR 1 (1), 1330:A / IR-Spectra (2), 430:H / IR-Spectra (3), 487:C / NMR-Reference 2 (1), 680:C / RegBook 1 (1), 965:J / Sigma FT-IR 1 (2), 249:C / Structure Index 1, 150:C:4 |
